Toxicity evaluation of YC1 in hSULT1A1 and mSULT1A1 mice 75N95025Q00237
Summary
AI-generated · Aug 25, 2025Evaluate YC1’s toxicity to establish its therapeutic window by conducting a head-to-head study in two mouse models: humanized SULT1A1 (hSULT1A1) mice and wild-type mice expressing mouse SULT1A1 (mSULT1A1). The goal is to determine differential safety and define the safety margin for YC1 in contexts where cancer cells express SULT1A1.
Use custom hSULT1A1 mice available from GemPharmaTech; compare toxicity outcomes between the humanized and wild-type SULT1A1 backgrounds to inform YC1’s potential clinical window.
NCATS seeks to determine if YC1 which works with a unique mechanism of cytotoxicity towards cancer cells that express SULT1A1. In doing so, NCATS shall establish the therapeutic window for YC1. To that end NCATS requires head-to-head comparison on YC1 in mice that have humanized SULT1A1 (custom mice available at GemPharmaTech) and with mouse SULT1A1 (wild type).
From Presolicitation posted on Aug 12, 2025Notice history
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Presolicitation LATEST Posted Aug 12, 2025
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