Smart Red Blood Cells (Smart-RBC) DARPA-PS-26-02
Summary
AI-generated · Oct 18, 2025DARPA seeks innovative proposals under the Smart Red Blood Cells program to engineer red blood cells with novel biological features that can safely, temporarily, and reliably alter human physiology. SRBCs would be engineered to contain three-layer biological circuits: sense extracellular biomarkers, decide next steps, and act by creating effector molecules that can alter metabolism or physiology. The program aims to push the art of the possible to create SRBCs to enhance human performance and maximize survival via hemostasis products.
This effort is research-focused and does not involve clinical trials or direct human testing within this program.
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in support of the Smart Red Blood Cells program (Smart-RBC). The DARPA Smart-RBC program aims to engineer red blood cells to contain novel biological features that can safely, temporarily, and reliably alter human physiology. Specifically, the Smart-RBC program will revolutionize blood products by creating smart red blood cells (SRBCs). SRBCs will be engineered to contain additional biological circuits consisting of three layers: Sense extracellular biomarkers; Decide next steps; Act by creating effector molecules that can alter metabolism or physiology. The program will identify the art-of-the-possible to create SRBCs to enhance human performance and maximize survival via hemostasis products. This program does not include clinical trials or direct human testing.
From Solicitation posted on Oct 17, 2025Notice history
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