Self-Administration System 75N95025Q00203SB
Summary
AI-generated · Aug 24, 2025Provide a self-administration system for preclinical rat research that enables researchers to assess social interaction behavior, drug self-administration, and compulsive drug-taking. This tool is intended to help determine how early social experiences influence vulnerability to substance use disorders by linking social experiences with drug-taking behavior and related brain-behavior relationships, with the goal of informing future prevention strategies and the development of more effective therapeutic interventions.
NRB previously identified that change in brain regions using the non-invasive imaging technique called functional magnetic resonance imaging (fMRI) associated with addiction vulnerability. This vulnerability can be measured by drug-taking behavior despite foot shock in rats. Early social experiences, including peer interactions, are critical for brain development and behavioral regulation. Disruptions in these experiences have been linked to increased risk of substance use disorders. However, it is unclear how social experiences affect vulnerability to substance used disorders. To shed light on this issue, the proposed self-administration system will allow researchers to evaluate social interaction behavior, drug self-administration and compulsive drug-taking behaviors. These behavioral assessments are essential for understanding how social experiences modulate brain-behavior relationships involved in substance used disorders. This finding is expected to inform future prevention strategies and supports the development of more effective therapeutic interventions for substance use disorders. Please see notice attached.
From Sources Sought posted on Jul 07, 2025Notice history
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