Self-Administration System 75N95025Q00203
Summary
AI-generated · Aug 24, 2025Self-Administration System for preclinical rodent studies is sought to enable researchers to evaluate social interaction behavior, drug self-administration, and compulsive drug-taking in rats. The effort builds on work linking early social experiences to brain development and addiction vulnerability, and aims to measure how social experiences modulate brain–behavior relationships involved in substance use disorders, with the goal of informing prevention strategies and supporting the development of more effective therapies.
The system should support behavioral assessments that can be integrated with neuroimaging insights (e.g., fMRI) to quantify addiction vulnerability, including scenarios where drug-taking persists despite punishing conditions such as foot shocks. This is a market-information request to gauge potential sources’ capabilities to provide or develop such a self-administration platform for preclinical research.
NRB previously identified that change in brain regions using the non-invasive imaging technique called functional magnetic resonance imaging (fMRI) associated with addiction vulnerability. This vulnerability can be measured by drug-taking behavior despite foot shock in rats. Early social experiences, including peer interactions, are critical for brain development and behavioral regulation. Disruptions in these experiences have been linked to increased risk of substance use disorders. However, it is unclear how social experiences affect vulnerability to substance used disorders. To shed light on this issue, the proposed self-administration system will allow researchers to evaluate social interaction behavior, drug self-administration and compulsive drug-taking behaviors. These behavioral assessments are essential for understanding how social experiences modulate brain-behavior relationships involved in substance used disorders. This finding is expected to inform future prevention strategies and supports the development of more effective therapeutic interventions for substance use disorders. Please see notice attached.
From Sources Sought posted on Jul 07, 2025Notice history
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