Regent of the University of Minnesota NIMH25007624
Summary
AI-generated · Aug 24, 2025Using a multiplex autoantibody assay to detect subclinical and preclinical autoimmune diseases, assess their seroprevalence in the Hispanic population, and investigate how autoantibody patterns relate to antibodies targeting infections and age-related conditions. The effort is grounded in the understanding that autoimmune diseases, while individually rare, collectively affect tens of millions, are more common in women, often co-occur, and can be underdiagnosed with autoantibodies appearing decades before disease onset.
The study aims to characterize these associations within Hispanics, exploring how autoantibody profiles correspond with infection-related and aging-related immune markers. This involves analyzing cross-links between autoimmune signatures and other antibodies to inform risk, detection, and potential prevention strategies.
Autoimmune diseases as single entities may be rare, but collectively afflict tens of millions of Americans and disproportionately impact women. Moreover, autoimmune diseases tend to co-occur in a person and are linked to many age-related conditions. In general, autoimmune diseases are underdiagnosed and involve autoantibodies that appear decades before the disease onset. Some autoimmune diseases occur more frequently in Hispanics, like systemic lupus erythematosus. Using a multiplex assay of autoantibodies to detect subclinical and preclinical autoimmune diseases, we propose assessing their seroprevalence in the Hispanic population and investigating the autoantibody associations with various antibodies to infection and age-related conditions.
From Special Notice posted on Jul 25, 2025Notice history
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USA