Proteomics Service 75N95025Q00234

DESCRIPTION: This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to provide equipment for this requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. BACKGROUND INFORMATION AND OBJECTIVE: The Neurobiology of Addiction Section goal is to understand the underlying biological mechanisms of alcohol and drugs of abuse dependence to search for better therapies for the treatment of these patients. We have specialized and complex animal models to study these disorders in parallel with samples from clinical trials of close collaborator laboratories. The ability to run these assays in clinical samples in parallel with our animal models would increase the impact and translatability of our findings. GENERIC NAME OF SERVICE: Proteomic Mouse Panel Analysis for the Investigation of Potential Biomarkers SALIENT CHARACTERISTICS: Capable vendors must demonstrate their ability to provide the following brand name or equal services: Must Encompass a minimum of 120 proteins. Must be able to target key pathways involved in inflammation, neurodegeneration and oncogenesis. Must be able to detect key low abundant targets such as p-tau217. Must cover immunology and neurology content. Must be able to identify potential therapeutic targets. Must perform ultra-high sensitivity and multiplexed analysis to support broad biomarker profiling and validation. QUANTITY: (Brand name or equal) NULISAseq Mouse Panel 120 Service: No. 901044. Qty. 5 INSTRUCTIONS: Companies that believe they possess the capabilities to provide the required services should submit documentation of their ability to meet each of the requirements to the Contracting Officer. The capability statement must specifically address each of the requirements separately. All capability statements must also include the following: 1) company name and address; 2) point of contact; 3) phone/fax/email; 4) NAICS Code(s); 5) business size and status; 6) capability information in response to the requirement and qualifications identified in this notice; and 7) type of small business your organization classifies itself as (i.e.: Women-Owned, HUBZone, etc.). Each capability statement must include the respondent s Unique Entity Identifier number, organization name, and address. Each response should include the technical and administrative points of contact, including names, titles, addresses, telephone numbers, and e-mail addresses. The capability statement should clearly identify the size and type of business (e.g., 8(a), HubZone, Non-Profit, Other Than Small Business, etc.), pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement paragraphs stated herein. A cover page and an executive summary may be included but is not required. Any business concerns that believe they possess the capability necessary to successfully undertake the work described above must SUBMIT CAPABILITY STATEMENTS ELECTRONICALLY to the Contract Specialist, Shaun Rostad at Shaun.Rostad@nih.gov, NO LATER THAN 1:00 p.m. EST on August 11, 2025. The Subject line for the submission should include this Sources Sought Number and organization name. NIDA will not accept paper or faxed capability statements. THIS NOTICE IS NOT A REQUEST FOR PROPOSALS. This notice is for information and planning purposes only and does not commit the Government to any contractual agreement. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation. CONFIDENTIALITY. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).

COMBINED SYNOPSIS / SOLICITATION-COMPETITIVE Title: Proteomics Service 1. This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested and a separate written solicitation will not be issued. 2. The solicitation number is 75N95025Q00234 and the solicitation is issued as request for quotation (RFQ). This acquisition is for a commercial item or service and is conducted under the authority of the FAR Part 13 Simplified Acquisition Procedures; and FAR Part 12 Acquisition of Commercial Items and is not expected to exceed the simplified acquisition threshold. A fixed-price type of purchase order is contemplated for this requirement. The National Institute on Drug Abuse (NIDA) requires the Proteomics Service to understand the underlying biological mechanisms of alcohol and drugs of abuse dependence to search for better therapies for the treatment of these patients. We have specialized and complex animal models to study these disorders in parallel with samples from clinical trials of close collaborator laboratories. The ability to run these assays in clinical samples in parallel with our animal models would increase the impact and translatability of our findings. See Attachment 1 Purchase Description, for additional details. 3. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2025-05, dated 08-07-2025. 4. The North American Industry Classification System (NAICS) Code for this procurement is 541380 Testing Laboratories and Services, and the small business size standard $19 million or less. 5. Line Items: Through this procurement NIDA anticipates a single award, firm fixed price purchase order for the Proteomics Service (Brand Name or Equal) as described in Attachment 1 Purchase Description. Below is a table that contains the line item numbers and description of the brand name or equal requirement for the anticipated award. Line No. Description 1 FY25. NULISAseq Mouse Panel 120 Service. 6. Project Requirements: Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to provide the required equipment as described in the Purchase Description. Please see Attachment 1 Purchase Description for the complete description and details of the requirement. 7. The anticipated delivery is thirty to ninety days after receipt of order. Additional details are identified in Attachment #1 - Purchase Description. 8. The provision at FAR clause 52.212-1, Instructions to Offerors Commercial Items, applies to this acquisition. 9. The provision at FAR clause 52.212-2, Evaluation Commercial Items, applies to this acquisition. The following is provided as an addendum to clause 52.212-2: The award resulting from this solicitation will be made to the responsible Offeror whose quote is most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate quotations: Technical Criteria, Price, and Options. A tradeoff process shall be used for this acquisition because it has been determined to be in the best interest of the Government to consider award to other than the lowest priced Offeror or other than the highest technically rated offeror. All evaluation factors and significant sub-factors are listed below in terms of their relative importance. Technical Factors are significantly more important than price. Evaluations will be based on the demonstrated capabilities of the prospective Offeror in relation to the needs of the project. The merits of each quote will be evaluated carefully. Each quote must document the feasibility of successful implementation of the requirements of this solicitation. The Offeror must submit information sufficient to evaluate its quotes based on the detailed factors listed below. A. Technical Evaluation Criteria As part of the Technical Quote, the Offeror shall include the following: i. Technical Capability and Functionality NIDA shall evaluate the offeror s technical approach for overall capability and functionality in relation to the General Requirement, Salient Characteristics, Quantity and Deliverables as described in the Statement of Work. ii. Contract Management and Customer Support NIDA shall evaluate the offeror s ability to provide a high level of customer service, particularly in the area of initial responsiveness and resolution of device and service problems. Specifically, the Government will evaluate the Offeror s capability based on its description of any applicable warranty, customer support process. iii. Past Performance The Offeror should provide past performance information. Past performance information should cover a minimum of 1 year in relevant services and deliveries of comparable systems. The Offeror should provide at least one reference for any project identified under the experience factor that has a performance period within the past three years. For each reference, the offeror should provide: (1) Organization/contracting partner's name; (2) Point of contact's (POC) name and contact information: Current phone numbers. Valid email addresses; (3) Description that precisely explains: General scope of the contract. Specific requirements of the contract. Offerors may be evaluated based on information obtained from references provided by the offeror, other relevant past performance information obtained from other sources known to the Government, and any information supplied by the offeror concerning problems encountered on the identified contracts and corrective action taken. Furthermore, the Government will assess the relative risks associated with each offeror. Performance risks are those associated with an offeror's likelihood of success in performing the acquisition requirements as indicated by that offeror's record of past performance. The assessment of performance risk is not intended to be the product of a mechanical or mathematical analysis of an offeror's performance on a list of contracts but rather the product of subjective judgment by the Government after it considers all available and relevant information. iv. Price Evaluation Offerors price quote will be evaluated for reasonableness. For a price to be reasonable, it must represent a price to the government that a prudent person would pay when consideration is given to prices in the market. Normally, price reasonableness is established through adequate price competition, but may also be determined through cost and price analysis techniques. Price evaluation will not be conducted on any Offeror determined to be technically unacceptable. 10. The Offeror is to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications Commercial Items, with its offer. 11. The FAR clause at 52.212-4, Contract Terms and Conditions Commercial Items, applies to this acquisition. 12. The FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items, applies to this acquisition and is supplemented by Attachment 2 - 52.212-5 Addendum. 13. The following additional contract requirement(s) or terms and conditions as determined by the Contracting Officer are necessary for this acquisition and consistent with customary commercial practices. FAR 52.212-4 Contract Terms and Conditions Commercial Items (October 2018) is included in this solicitation by reference. Additional contract requirement(s) or terms and conditions determined by the Contracting Officer to be necessary for this acquisition are supplemented by the following attachments: Attachment 1 Purchase Description Attachment 2 - 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items Attachment 3 Invoice Instructions 14. This is not a rated order under the Defense Priorities and Allocations System (DPAS). The resultant purchase order will provide that HHS reserves the right to exercise priorities and allocations authority with respect to this contract, to include rating this order in accordance with 45 CFR Part 101, Subpart A Health Resources Priorities and Allocations System. 15. The response to the combined synopsis/solicitation is due no later than September 3, 2025 at 1:00 P.M. Eastern Standard Time (EST). Offers submitted after the deadline may not be considered. The response should be submitted in a searchable electronic format to the Contract Specialist, Shaun Rostad at Shaun.Rostad@nih.gov. Electronic submittals must include the combined synopsis/solicitation 75N95025Q00234 and the Title in the Subject Line. In addition, the Unique Entity Identifier (UEI) number, the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. The Offeror must submit with their quote the following information: technical quote in accordance with this combined synopsis/solicitation in a searchable PDF format; Price quote in an Excel format; the Unique Entity Identifier (UEI) number; and Verification of System for Award Management (SAM) Registration www.sam.gov. Technical quotes shall be submitted in accordance with the Project Requirements identified in Section 6 of this combined synopsis/solicitation. The Offeror should submit a separate business quotes in searchable PDF format. In its business quote, the Offeror shall add the total price for the basic requirements. Any quote, modification, or revision that is received at the designated Government office after the exact date and time specified for receipt of quotations is late and may not be considered. Quotes received late may not be evaluated or considered for award and may be returned to the Offeror. If an emergency or unanticipated event interrupts normal Government processes so that quotes cannot be received at the Government office designated for receipt of quotes by the exact time specified in the solicitation, and urgent Government requirements preclude amendment of the solicitation closing date, the time specified for receipt of quotes will be deemed to be extended to the same time of day specified in the solicitation on the first work day on which normal Government processes resume. The Government reserves the right to award without discussions if the Contracting Officer determines that the initial prices are fair and reasonable and that discussions are not necessary. 16. Questions and requests for clarification should be submitted electronically to the Contract Specialist, Shaun Rostad at Shaun.Rostad@nih.gov on or before 1:00 pm August 29, 2025. Any questions or request for clarification must include the combined synopsis/solicitation 75N95025Q00234 and the Title in the Subject Line.