Maintenance Agreement for EQUIPMENT SARTORIUS 75N98026Q00636

The Contractor shall provide all labor, material and equipment necessary to maintain and provide preventive maintenance for Incucyte SX5 serial # IC70655. The NCI studies the cellular response to DNA damage in order to identify novel targets, as well as targetable synthetic lethal interactions, to augment cancer therapies, including radio and chemotherapy. The characterization and validation of these targets requires the detailed analysis of the response of many cell lines to a wide combination of drug treatments and genetic modifications. The IncuCyte SX5 system allows this to be done in an efficient and high throughput manner, requiring less hands-on time from investigators, and on a smaller scale, thus reducing costs due to the requirement for fewer consumable reagents. In addition, the IncuCyte SX5 system collects data in an automated, real-time fashion, so that multiple investigators from different labs can perform experiments in parallel, and it allows data collection over weekends and holidays, maximizing the data output of the experiments. The system is used frequently to collect real time data about the timing and mode of cancer cell death in response to a variety of experimental treatments, to measure cell proliferation, to measure the presentation and recruitment of immune modulating surface markers (ex. PD-L1) and to measure cell migration and invasion. Given the near constant use in a humidified environment, the system requires preventitive maintenance and frequent adjustments to avoid costly repairs and downtime. All maintenance services shall be performed on-site in accordance with the manufacturer s standard commercial maintenance practices.